SPORADIC, FAMILIAL AND SUSPECTED FAMILIAL IgA Nephropathy (IgAN)
IgAN may occur in a sporadic , familial or suspected familial form according to the following protocol:
Familial IgAN is diagnosed when at least 2 family members have biopsy-proven IgAN.
Sporadic IgAN is diagnosed when the disease occurs only in one subject and all family members have negative urinalysis.
Suspected familial IgAN is defined when the presence of the disease occurs in one family member and other individuals of the same pedigree have minimal urinary abnormalities or manifested disease and refuse renal biopsy.
|Families with single generation (SG) involvement have no more than one generation showing any manifestation of the disease.
|Families with multiple generations (MG) involvement eevidence vertical transmission of the trait, with individuals from two or more generations affected.
IgAN AFFECTED SUBJECTS are defined those with biopsy-proven IgAN.
PROBABLY AFFECTED SUBJECTS are defined those with persistent microscopic hematuria who refuse renal biopsy and family members with chronic renal insufficiency or with end stage kidney disease requiring renal replacement therapy, as dialysis or organ transplantation
APPARENTLY HEALTHY SUBJECTS are are defined those without urinary abnormalities and negative nephrological history.